Advancing Minimally Invasive and Transcatheter Valve Therapies

The history of surgery for valvular heart disease at Brigham and Women’s Hospital (BWH) dates to May 1923 when Elliott Carr Cutler, MD, performed the first ever valve operation in the world. Since then, BWH has been at the forefront of the clinical practice and innovation in the management of valve disease. Read More

CANTOS Update: Response After Single Treatment with Canakinumab Predicts Which Patients Will Benefit Most

A new analysis seeks to answer the question of which patients are likely to gain the greatest cardiovascular benefit when treated with the anti-inflammatory agent canakinumab. At the 2017 American Heart Association Scientific Sessions, Paul M. Ridker, MD, director of the Center for Cardiovascular Disease Prevention at Brigham and Women’s Hospital, presented a pre-specified analysis on CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcomes Study) that identifies a simple, clinical method to define patient groups most likely to benefit from long-term canakinumab treatment. The results of this analysis, published simultaneously in The Lancet, could have a major impact not only on patient selection and cost-effectiveness of canakinumab, but also on the future development of anti-inflammatory agents for cardiovascular disease. Read More

Comprehensive Atrial Fibrillation Program Offers Collaborative and Innovative Care

Cardiac electrophysiologist and arrhythmia specialist Paul C. Zei, MD, PhD, joined the Heart Rhythm Disorders Program at Brigham and Women’s Hospital (BWH) as director of the Comprehensive Atrial Fibrillation Program (CAFP) with the goal of establishing it as one of the leading programs in the world for managing patients with atrial fibrillation (AF).  Read More

Organ-on-a-Chip Model Offers Insights into Premature Aging and Vascular Disease 

deviceResearchers have been able to generate induced pluripotent stem cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) to better understand the mechanisms of aging and look for new treatments. Read More

Case Study: Minimally Invasive Option for Ascending Aortic Pseudoaneurysm 

Cardiac surgeons at Brigham and Women’s Hospital performed an innovative endovascular procedure to treat a ruptured ascending aortic pseudoaneurysm. Read More