Improving Survival Benefit in Glioblastoma Patients with Neoadjuvant Immunotherapy

MR images of a brain at baseline vs. ONC201 A new study featured on the cover of the March issue of Nature Medicine offers hope for treating patients with glioblastoma. In a small randomized controlled clinical trial, patients with recurrent glioblastoma lived nearly twice as long if they received an immunotherapy drug prior to and following surgery, compared to patients who only received the drug after surgery.
Read More

MR-Guided Radiation Therapy: A More Precise Way to See, Track and Treat Tumors

New MR-Imaging (Left) – Traditional Cone-beam CT (Right)
New MR-Imaging (Left) – Traditional Cone-beam CT (Right)

For the first time, cancer patients in New England will have a cutting-edge option for radiation treatment of soft-tissue tumors. The new MR-Guided Radiation Therapy (MR-RT) treatment at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), launching this summer, will give physicians real-time, pinpoint accuracy for radiation planning and treatment.
Read More

New Hope for Late-Stage Endometrial Cancer Patients

drawing of DNA double helix with the phrase Novel therapies in Endometrial CancerWhen diagnosed and treated in its early stages, endometrial cancer is largely curable. However, for the 10 to 15 percent of patients diagnosed with late-stage disease, standard therapy does not lead to a cure.
Read More

Leading the Country in the Care of Patients with Hereditary GI Cancers

Blood samples in laboratory (coagulation test)Over the past two decades, the Dana-Farber/Brigham and Women’s Cancer Center  (DF/BWCC) has become a national leader in the care of patients with hereditary gastrointestinal cancers, from Lynch syndrome to polyposis syndromes.
Read More

Neurotoxicity Associated With CAR T Cell Therapy

drawing of a Chimirc Antigen ReceptorChimeric antigen receptor T (CAR T) cell therapy has become an important tool in the treatment of relapsed and refractory malignancy. However, it is associated with significant and unique neurological toxicities.

A multidisciplinary team of clinicians at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) are among the first in the nation to study this issue as a team prospectively; their findings are about to be published in the journal Brain.
Read More

New Center Addresses Research and Treatment Challenges in Young-Onset Colorectal Cancer

colorectal cancer cells stained under a microscopeColorectal cancer remains a major health problem in the United States. It’s the third most common type of cancer and the second leading cause of cancer death.

While the incidence of colorectal cancer is decreasing somewhat in the population, it has increased by 51 percent in people under the age of 50. This trend is expected to continue, with an estimated 90 percent increase in colon cancer incidence and 124 percent increase in rectal cancer incidence by 2030.
Read More

Expanding the Frontiers of Breast Cancer Immunotherapy

Pipette dropping stem cell research fluid on pcr plate. Medical Dropper

Elizabeth A. Mittendorf, MD, PhD, a breast cancer surgeon and international leader in breast cancer vaccines, recently joined Brigham and Women’s Hospital (BWH) from the MD Anderson Cancer Center in Houston, where her research focused on vaccines that target the HER2 protein expressed on many breast tumors. At the Brigham, her work focuses on advancing our understanding of breast cancer immunotherapies.

Read More

Increasing First-Line Treatment Options for Advanced Kidney Cancer

Human kidney cross section on scientific backgroundA drug whose clinical testing was led by Toni K. Choueiri, MD, of Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), has become a standard first-line therapy for certain newly diagnosed patients with advanced kidney cancer. Additionally, several combination therapies are being used or tested at DF/BWCC and elsewhere against this aggressive cancer.
Read More

Could ‘Precursor Escape’ Explain Advanced High-Grade Serous Carcinoma?

Over a decade ago, Christopher Crum, MD, of Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), helped design the protocol that revealed the fallopian tubes to be the origin of most high-grade serous carcinomas (HGSCs), the tumor type afflicting over two-thirds of women with ovarian cancer.

Read More

Case Study: Cancer Diagnostic Service (CDS) Expedites Next Steps in Care

Louise I. Schneider, MD, a member of the Cancer Diagnostic Service team, discusses next steps with a patient.

For clinically complex patients who present with signs or symptoms of cancer, the Cancer Diagnostic Service (CDS) at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC) can expedite a diagnosis and avoid unnecessary testing and delays.

Read More