Focused Ultrasound: Noninvasive Surgery Stops Tremor in its Tracks

Image courtesy of INSIGHTEC

Each week, two or three patients with medically refractive essential tremor undergo  MRI-Guided Focused Ultrasound (MRgFUS) Thalamotomy at Brigham and Women’s Hospital, with often-life-changing results – fulfilling the promise of a technology that dawned here 20 years ago.

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Link Between Hearing Problems and Accidental Injuries

Lund, Sweden - April 11, 2016: Real life in the city. Elderly woman is out walking, crossing a street with her walker. No traffic visible.

As the American population ages, a greater percentage of people will suffer from moderate to severe hearing loss. Research shows that older people also are at a higher risk of accidental injuries.

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Repairing Lateral Sphenoid Cerebrospinal Fluid Leaks Endoscopically

Cerebrospinalfluid (CSF) leaks in the lateral recess of the sphenoid (LRS) are rare. For cases in which they do occur, however, Brigham and Women’s Hospital offers a minimally invasive, endoscopic alternative to traditional open surgery.

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No Wrong Door: Bridging Continuity of Care in Addiction Treatment

The staff of the Brigham health bridge to recovery clinic

In the face of America’s growing opioid crisis, Brigham and Women’s Hospital has introduced an innovative new service to help patients with addiction abuse disorder get the immediate care they need. Opened in spring 2018, the Bridge Clinic immediately connects patients being discharged from the hospital and emergency department with treatment and services.

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Increasing First-Line Treatment Options for Advanced Kidney Cancer

Human kidney cross section on scientific backgroundA drug whose clinical testing was led by Toni K. Choueiri, MD, of Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), has become a standard first-line therapy for certain newly diagnosed patients with advanced kidney cancer. Additionally, several combination therapies are being used or tested at DF/BWCC and elsewhere against this aggressive cancer.
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Mapping Monocyte States in Class IV Human Lupus Nephritis

Paul Hoover Headshot
Paul J. Hoover, MD, PhD

Prior work in Lupus Nephritis has shown that immune cell infiltration, especially that of monocytes, is associated with pathologic tissue remodeling and declining renal function. A deeper understanding of infiltrating monocytes could yield more accurate interpretations of histopathologic lesions, better disease predictors, and new therapeutic concepts. Newer technologies offer a promising path toward this goal. Single cell-RNA sequencing (scRNA-seq) enables the molecular classification of cell states based on the expression of thousands of genes, and multiplex-immunofluorescent imaging enables precise spatial localization of these cell states in the context of diseased tissue. Groundwork to merge these technologies derives from our work with the Accelerating Medicines Partnership (AMP) consortium.
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Elucidating the Biology and Role of Synovial Fibroblasts in Rheumatoid Arthritis

kevin wei headshot
Kevin S. Wei, MD, PhD

Synovial fibroblasts are mesenchymal cells in the synovium that regulate tissue homeostasis in healthy joints. However, in rheumatoid arthritis (RA), synovial fibroblasts assume pathological functions as they recruit infiltrating immune cells that degrade cartilage and bone, leading to joint damage.  Therapies aimed at synovial fibroblasts in RA have the theoretical potential to prevent joint damage while sparing side-effects from immunosuppression. However, incomplete understanding of synovial fibroblast heterogeneity and the pathways that regulate their identity pose major challenges to the therapeutic targeting of these cells.  We sought to attack this problem by applying cutting-edge single cell technology to examine the biology of synovial fibroblasts in RA.
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Development of a Set of Potentially Preventable Adverse Conditions Specific to Lupus: A Delphi Consensus Study

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Candace H. Feldman, MD, MPH, ScD

It is estimated that at least 25 percent of all individuals with lupus are hospitalized each year. These hospitalizations tend to be associated with significant morbidity and mortality and are costly for the health care system. The U.S. Agency for Healthcare Research and Quality (AHRQ) developed a set of prevention quality indicators which they defined as conditions that “should be treatable on an outpatient basis, or that could be less severe if treated early and appropriately.” The AHRQ has used this set of “ambulatory care sensitive conditions” to identify populations at risk for hospitalization and to better understand the breakdown of health care services for these vulnerable groups. Examples of these conditions include diabetic complications, pulmonary disease (e.g. asthma) exacerbations, and pyelonephritis.
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Abdominal Obesity and Risk of Developing Rheumatoid Arthritis in Women

Bing Lu headshot
Bing Lu, MD, DrPH

Individuals with obesity, particularly abdominal obesity, are at an increased risk of hypertension, dyslipidemia, diabetes, coronary heart disease, stroke, cancer, and all-cause mortality. Several studies have observed an association between obesity and increased risk of rheumatoid arthritis (RA). Abdominal obesity is associated with visceral fat and has been a stronger predictor of obesity-related health risk, such as cardiovascular disease, than overall obesity as measured by BMI. We sought to investigate whether abdominal obesity per se predicts RA risk in two large prospective cohorts, the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII).
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Older Patients Requiring Surgery After a Bone Fracture Benefit from GIFTS Program

Elderly patient lying in bed and having blood pressure measuredFalls that lead to bone fractures occur frequently in older people. These injuries, especially those that require surgery, often start patients down a path toward mounting health problems that threaten their ability to live independently or maintain a good quality of life.
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