Metabolism is a hot topic in immunology. Immune cells carry out diverse functions by exploiting different pathways of taking in nutrients and generating energy. Accordingly, metabolic processes such as glycolysis and oxidative phosphorylation are now front and center in understanding how cells behave in the context of normal and pathogenic immune responses. Read More
The inflamed joint is a complex place. Many different types of cells must interact with each other to initiate and sustain inflammation and tissue injury. These include both those resident in the joint before inflammation started and cells that were recruited or developed later. To get a handle on this complexity, investigators need methods that can provide highly detailed portraits of individual cells. A major goal of the Joint Biology Consortium’s Cellular Systems Core, directed by Dr. Jim Lederer, is to accelerate research by JBC members through two such methods: cytometry by time of flight (CyTOF) mass cytometry and RNA sequencing (RNA-seq). Read More
A single genetic variant in PTPN22 has been known for over a decade to convey risk for rheumatoid arthritis (RA), but exactly how remains a mystery. Led by rheumatologist and researcher Dr. I-Cheng Ho, investigators at BWH are using the JBC to understand PTPN22 as a regulator of citrullination, the post-translational protein modification of arginine that plays a leading role in RA biology. Read More
Conducting high-quality translational research in rheumatology is increasingly difficult. Major projects often require a range of methods, from patient recruitment to cutting-edge ‘omics technologies to big-data bioinformatics. Most research groups lack the expertise to cover this range, and so must either limit the scope of their work or expend substantial effort working outside their “comfort zone” to achieve their research goals. Neither of these options efficiently advances the science of rheumatology.
Cynthia Morton, PhD
In the effort to identify genetic drivers of fibroids, the lab of Cynthia Morton, PhD, at Brigham and Women’s Hospital (BWH) is at an international crossroads. In recent years, Morton and investigators worldwide have been studying the molecular and genetic background of fibroids that may contribute to their development and growth.
The increasing frequency of placenta accreta is raising new questions about the best way to manage this dangerous condition. At Brigham and Women’s Hospital researchers are creating a body of data to learn if some women with previa-accreta can be selected for a later delivery, if placenta accreta requires general anesthesia, and potential future risks for women who have had accreta during pregnancy.
The hybrid operating room at the Brigham and Women’s Hospital Heart & Vascular Center now features the state-of-art ARTIS Pheno angiography system. As of March 2018, patients who require hybrid cardiovascular interventions combining intravascular and open surgical procedures are reaping the rewards of this cutting-edge technology.
Advanced heart failure patients who received the HeartMate 3 left ventricular assist device (LVAD) in the MOMEMTUM 3 trial had fewer strokes and re-operations for pump malfunction compared with its predecessor, the HeartMate 2. The findings from Brigham and Women’s Hospital were published in the New England Journal of Medicine earlier this year and simultaneously presented at the 2018 American College of Cardiology Scientific Sessions.